B-catenin in Cutaneous Squamous Cell Carcinoma and Its Mimickers

Sohag University

Status: Enrolling

Conditions: Cutaneous Squamous Cell Carcinoma

Treatments: Biological: Immunohistochemical staining

Study type: Observational

Funder types: Other

Identifiers

NCT06536946

Soh-Med-25-05-07MS

Details and patient eligibility

About

Examine the role of B-catenin in differentiation of cutaneous squamous cell carcinoma from other lesions that may be similar to it

Full description

Skin cancer is one of the most common form of cancer worldwide. Cutaneous squamous cell carcinoma is one of most common skin tumers that caused by many factors as ultra violet ,ionizing radiation and others . It was an advanced spectrum ranging from actinic keratosis to invasive and metastatic squmous cell carcinoma. Correct identification of cutaneous squamous cell carcinoma is a challenge as it has both clinically and histopathologically mimickers.

So the aim of this study is to identify the expression of B-catenin in cutaneous Squamous cell carcinoma and its mimickers.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• tissue blocks with sufficient materials Cases with sufficient data

Exclusion criteria

• tissue blocks with insufficient and necrotic materials. Casas with insufficient data

Trial design

50 participants in 1 patient group

Participants

Description:

50 formalin fixed parrafin embedded tissue blocks of cutaneous squamous cell carcinoma and its mimickers , from each block 2 tissue section; one tissue section stained by Hematoxilin and Eoisin and other tissue section will be stained immunohistochemically by anti human B-catenin

Treatment:

Biological: Immunohistochemical staining