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B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma (polymorphism)

A

Assiut University

Status

Unknown

Conditions

Asthma
Gene Abnormality

Study type

Observational

Funder types

Other

Identifiers

NCT03118869
AssiutU3

Details and patient eligibility

About

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance.

The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.

Full description

Asthma is a complex disease and has a strong genetic component in its pathogenesis. So far, considerable efforts have been made to evaluate the association between genetic variants and asthma risk, and numerous genes have been identified as asthma Reporting Items susceptible genes.

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance.

The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.

Enrollment

75 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • patients diagnosed as asthma according to GINA guideline 2016.
  • Allergic asthma

Exclusion criteria

  • pneumonia
  • chronic cardiac, hepatic and renal diseases
  • pregnancy and lactation
  • malignancy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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