Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals

Centre Hospitalier Universitaire de Nice

Status: Enrolling

Conditions: Infections; Sepsis

Treatments: Biological: Premature neonates with invasive infection caused by Bacillus cereus

Study type: Observational

Funder types: Other

Identifiers

NCT06973174

25LaboBacterio01

Details and patient eligibility

About

Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death.

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Enrollment: 40 estimated patients

Sex: All

Ages: Under 143 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Premature newborn (i.e born before 37 last menstrual periods) with invasive infection caused by B. cereus (strains isolated from blood culture and cerebrsopinal fluid)

Exclusion criteria

• None