Background of Different Phenotypes of Coeliac Disease

Tampere University Hospital

Status: Enrolling

Conditions: Celiac Disease; Dermatitis Herpetiformis

Treatments: Genetic: Genetic predisposition

Study type: Observational

Funder types: Other

Identifiers

NCT05597904

R22088

Details and patient eligibility

About

The main purpose of this study is to investigate genetic, serological, immunological and microbiata diversities between different coeliac disease phenotypes and to discover applicable prognostic markers for specific phenotypes.

Full description

The recognition of clinical heterogeneity has expanded the understanding of coeliac disease, but the factors contributing to this diversity remain unclear. Moreover, since coeliac disease is highly heterogeneous, there is a need for more individualized follow-up and support and implementation of more personalized follow-up guidelines.

In this study coeliac disease and dermatitis herpetiformis patients and healthy controls will be recruited. Genetic, clinical, immunological, micobiata and novel biomedical markers are compared between coeliac disease phenotypes and also controls and their prognostic value is assessed.

Enrollment: 3,500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis
• Cohort 3: friend or non-related family member of coeliac disease or dermatitis herpetiformis patient

Exclusion criteria

• Cohorts 1-3: Age <18 years
• Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis not confirmed
• Cohort 3: coeliac disease or dermatitis herpetiformis diagnosis

Trial design

3,500 participants in 2 patient groups

Coeliac disease patients

Description:

Adult (18 years or over) patients with previous coeliac disease or dermatitis herpetiformis diagnosis

Treatment:

Genetic: Genetic predisposition

Healthy controls

Description:

500 adult (18 years or over) friends or non-related family members of coeliac disease or dermatitis herpetiformis patients participating in the study, no previous coeliac disease or dermatitis herpetiformis diagnosis. In addition 1000 controls will be included from Biobank

Treatment:

Genetic: Genetic predisposition