Bacterial Infections in Cirrhotic Patients With Acute Severe Liver Injury

The Zhejiang Study Group for Organ Failure in Cirrhosis

Status: Unknown

Conditions: Cirrhosis, Liver; Acute Liver Injury; Bacterial Infections

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03204591

NSFC81670567

Details and patient eligibility

About

Acute hepatic insults including hepatitis flare-up, active alcohol assumption and hepatotoxic drug use are common in patients with cirrhosis especially in Eastern countries.These patients are at high risk of developing acute-on-chronic liver failure (ACLF) and associated with high short-term mortality. And the natural history of these patients is frequently complicated by bacterial infections, which lead to deterioration of underlying diseases. The present study is aimed to investigate the prevalance and risk factors of bacterial infections in those patients and its impact on in-hospital/short-term mortality.

Enrollment: 500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The presence of cirrhosis confirmed by liver biopsy, endoscopy, radiological examination, or clinical evidence of prior hepatic de-compensation;
2. Flare up of acute severe liver injury within one month before enrollment. Acute severe liver injury is defined as: increase of serum bilirubin >=85mmol/L and international normalized ratio (INR)>=1.5 with a definite hepatic insult.

Exclusion criteria

(1)pregnancy; (2) disseminated maliganancy; (3)previously received a liver transplant; (4) HIV infection;

Trial design

500 participants in 1 patient group

LC with SALI

Description:

cirrhosis patients with severe acute liver injury

Treatment:

Other: No intervention