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Bacteriotherapy to Improve Underarm Odor

U

University Ghent

Status and phase

Completed
Phase 2

Conditions

Bromhidrosis

Treatments

Biological: Bacterial spray

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The goal is to improve the underarm odor by changing the microbiome. The autochthonous bacterial community is replaced by a non-smelling microbiome, by daily application of bacteria in a spray.

Full description

Participants are recruited and selected based on their initial underarm odor and underarm microbiome. The participants use two sprays: one spray containing the bacteria, and the other nothing (placebo). Participants do not know which spray they have. They use one spray during one month, and meanwhile take samples of their underarm microbiome (for sequencing), volatome (for GC/MS analysis) and odor (for odor panel analysis). Samples are stored in the freezer and brought to the university after one month, when they receive the second spray. The bacterial spray contains bacteria that are correlated with good underarm odor.

Enrollment

67 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • above average underarm malodor
  • microbiome dominated with malodorous bacteria

Exclusion criteria

  • not healthy
  • microbiome with too high levels of Staphylococcus

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

67 participants in 2 patient groups, including a placebo group

Placebo arm
Placebo Comparator group
Description:
Placebo spray used during one month
Treatment:
Biological: Bacterial spray
Treatment arm
Active Comparator group
Description:
Bacteria spray used during one month
Treatment:
Biological: Bacterial spray

Trial contacts and locations

1

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Central trial contact

Floor Van Herreweghen, PhD; Chris Callewaert, PhD

Data sourced from clinicaltrials.gov

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