Bariatric Surgery and Pharmacokinetics of Metoprolol

N

Norwegian University of Science and Technology

Status

Enrolling

Conditions

Obesity, Morbid

Treatments

Drug: Metoprolol

Study type

Observational

Funder types

Other

Identifiers

NCT03519906
2016/1145u

Details and patient eligibility

About

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on metoprolol are investigated.

Enrollment

12 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
  • Being a Norwegian citizen

Exclusion criteria

  • Having previously undergone resections in the GI-tract

Trial contacts and locations

1

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Central trial contact

Magnus Strømmen, MSc

Data sourced from clinicaltrials.gov

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