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The primary objective of this study is to evaluate if, in patients with severe obesity (body mass index (BMI) ≥35 kg/m2) and high-risk cardiovascular disease (CVD), bariatric surgery compared to medical weight management (MWM) safely reduces the risk of major cardiovascular events. The cost-effectiveness of bariatric surgery will also be examined. Separate sub-studies will be performed to examine the relationship between bariatric surgery and mental health, cardiac structure and function, genomics, proteomics and metabolomics.
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Inclusion criteria
Body mass index ≥35 kg/m2
Age ≥18 years
High-risk CVD, defined as the presence of any one of the following:
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
2,000 participants in 2 patient groups
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Central trial contact
Tara McCready
Data sourced from clinicaltrials.gov
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