Barley Beta-glucan, Glycemic Control, and Appetite
Status
Completed
Conditions
Appetitive Behavior
Diabetes
Appetite and General Nutritional Disorders
Blood Sugar; High
Diet, Healthy
Treatments
Other: WR+50g HFCS
Other: LB + 50 g HFCS
Other: HB + 50 g HFCS
Other: LB
Other: MB
Other: WR
Other: HB
Other: MB + 50 g HFCS
Details and patient eligibility
About
Novel barley varieties high in the soluble fiber β-glucan have the capacity to improve population health through improving glycemic control. Sweetened and unsweetened wholegrain barley foods were tested in a randomized, controlled, crossover human clinical trial to assess impact on postprandial appetite and food intake.
Enrollment
16 patients
Sex
All
Ages
18 to 50 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- 18-50 years of age
- Body Mass Index (BMI) values of 18.5-40.0 kg/m2
- Normal fasting blood glucose (<100 mg/dL)
Exclusion criteria
- Use of medications known to be associated with weight change (e.g., beta-blockers)
- Use of steroid pills or shots such as prednisone or cortisone
- Use of nicotine
- Weight change of ten or more pounds in the last three months
- Major daily variation in physical activity (e.g., athletes in training)
- History of extensive small bowel surgery or surgery to treat obesity
- History of heart attack, stroke, or bypass
- History of cancer within the last five years (exception: non-melanoma skin cancer)
- Recent or current medical diagnosis or medical treatment that would alter appetite, energy needs, satiety, and/or could impact the results of the trial
- Medical diagnoses of diabetes, cardiovascular disease, high levels of blood lipids, asthma, cold, and flu (exception: hypertension, if treated with medication prescribed more than three months prior to the screening activity)
- Fear of blood or needles
- Dietary restrictions that would interfere with consuming test foods (e.g., gluten intolerance, vegan, corn syrup allergy)
- Following a weight modification diet
- Sensitive to food textures present in the test foods
- Following personal schedules that would not permit attendance at all scheduled testing sessions
- Unable to comprehend the nature of the trial or instructions
- Unable to understand English sufficiently to complete the trial
Trial design
Primary purpose
Prevention
Allocation
Randomized
Interventional model
Crossover Assignment
Masking
Double Blind
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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