Barotrauma in Adults With Critical COVID-19

Karolinska Institute

Status: Completed

Conditions: COVID-19; Barotrauma

Treatments: Procedure: Invasive mechanical ventilation; Procedure: Open system; Procedure: Non-invasive mechanical ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT05877443

Barotrauma COVID-19

Details and patient eligibility

About

During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19. If this is complications of the respiratory support used to treat patients hypoxemia or if it is a direct consequence of COVID-19 damaging the lung tissue is not known.

The aim of this study is to investigate the incidence and type barotrauma, if there is an association between barotrauma and level of respiratory support used in the intensive care unit, and if barotrauma is associated with worse outcome compared to patients without barotrauma.

Enrollment: 669 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Positive polymerase chain reaction for SARS-CoV-2
• Admitted to ICU due to respiratory failure

Exclusion criteria

• Transferred to or from an ICU in other hospital/region making data collection regarding baseline data/outcomes not possible

Trial design

669 participants in 3 patient groups

Respiratory support by an open system

Treatment:

Procedure: Open system

Respiratory support by non-invasive mechanical ventilation

Treatment:

Procedure: Non-invasive mechanical ventilation

Respiratory support by invasive mechanical ventilation

Treatment:

Procedure: Invasive mechanical ventilation