Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock

Herlev Hospital

Status: Unknown

Conditions: Septic Shock

Treatments: Procedure: Measurement of inflammatory markers in the rectal mucosa; Procedure: Rectal biopsy; Procedure: Measurement of rectal lactic acid

Study type: Observational

Funder types: Other

Identifiers

NCT00378586

KA-05037

Details and patient eligibility

About

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers.

The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Septic shock

Exclusion criteria

• Age < 18 years
• No next of kin
• Pathology of the descending or sigmoid colon or rectum
• Pregnancy
• 1st degree relatives with inflammatory bowel disease
• Severe coagulopathy