Bartonella in Liver Transplant Patients

University of Minnesota (UMN)

Status: Completed

Conditions: Cryptogenic Cirrhosis; Cryptogenic Chronic Hepatitis

Treatments: Other: Blood collection; Other: Urine sample collection; Other: skin punch biopsy collection

Study type: Observational

Funder types: Other

Identifiers

NCT02595710

1312m46162

Details and patient eligibility

About

Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood, skin and urine samples will be analyzed for Bartonella spp..

Full description

Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood samples will be analyzed for Bartonella using the state-of-the art Bartonella Alpha Proteobacterium Growth Medium (BAPGM) multi-platform testing, including liquid culture, enriched agar plating and molecular techniques. Blood smears will be analyzed for intra-erythrocytic Bartonella spp. Four-millimeter skin biopsies from non-lesional skin will be acquired from the same patients, processed using our published techniques, and imaged using confocal microscopy and compared to BAPGM test results. additionally, urine samples will be collected and analyzed for microRNAs.

Enrollment: 3 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• o Male and female subjects, ages 18 years and older

  • Liver transplant recipient
  • Diagnosis of cryptogenic cirrhosis
  • Signed consent form

Exclusion criteria

• none

Trial design

3 participants in 1 patient group

Biospecimen retention

Description:

Blood Collection Skin Punch Biopsy Collection Urine Sample Collection

Treatment:

Other: Blood collection

Other: Urine sample collection

Other: skin punch biopsy collection