Basal Bolus vs. Sliding Scale for Treatment of Diabetic Patients in Medical Wards

HaEmek Medical Center, Israel

Status and phase

Completed

Phase 4

Conditions

Diabetes Mellitus Type 2

Treatments

Drug: Insulin, regular - act rapid

Drug: Insulin glulisine, Insulin glargine

Study type

Interventional

Funder types

Other

Identifiers

NCT01594060

0042-12-EMC

Details and patient eligibility

About

A comparison of two treatment approaches for hyperglycemia in diabetic patients hospitalized in the medical department. The first approach is called basal-bolus in which 4 insulin shots are given daily ( 3 short acting before meals and one long acting before bed time). The second approach is called sliding scale in which short acting insulin alone is given before meals and before bed time according to the patient's glucose values. The aim is to keep fasting glucose between 140-180 mg/dl.

Enrollment

36 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients admitted to internal medicine ward with blood glucose (BG) between 140-400 mg/dl.
Known history (>6months) of diabetes.
Aged 18-80 years old.
Previous therapy including either diet alone or any combination of oral hypoglycemia agents, glucagon-like peptide 1 (GLP-1) analogs and long acting insulin analogs or Neutral Protamine Hagedorn (NPH).

Exclusion criteria

Pregnancy
Patients with ketoacidosis
Patients with unknown history of diabetes
Patients with type 1 diabetes mellitus
Patients with clinically relevant hepatic disease or renal impairment ( serum creatinine≥2.5 mg/dl)
Use of corticosteroid therapy
Patient with any mental disorder preventing him to cooperate and give informed consent.
Patients on multiple daily doses of insulin regimen.