Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders

University of Aarhus

Status: Completed

Conditions: Hyperlipidemia; Arterial Hypertension; Diabetes Mellitus; Obesity; Metabolic Syndrome

Treatments: Other: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer

Study type: Interventional

Funder types: Other

Identifiers

NCT01571609

1-10-72-113-12

Details and patient eligibility

About

The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.

Enrollment: 40 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• 18-70 years of age
• Member of Biobank Vejle
• BMI<30

Exclusion criteria

• Diabetes mellitus
• Severe illness

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Carriers

Experimental group

Treatment:

Other: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer

Non-carriers

Experimental group

Treatment:

Other: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer