BCAAs, Muscle Protein Synthesis and Glucose Uptake

W

Wageningen University

Status

Enrolling

Conditions

Healthy

Treatments

Dietary Supplement: Ingestion of an amino acid supplement

Study type

Interventional

Funder types

Other

Identifiers

NCT06218264
NL82984.028.23

Details and patient eligibility

About

The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.

Full description

Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).

Enrollment

28 estimated patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Aged from 18-35 years
  • 18.5 < Body mass index < 30 kg·m2
  • Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)

Exclusion criteria

  • Smoking
  • Diabetes (Type 1, Type 2, or genetic form of diabetes)
  • Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
  • Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
  • Known allergy to lidocaine
  • Regular use of dietary protein and/or amino acid supplements (>3 times per week)
  • Currently involved in a structured progressive resistance training programme (>3 times per week)
  • A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
  • Any previous motor disorders or disorders in muscle and/or lipid metabolism
  • Presence of an ulcer in the stomach or gut and/or strong history of indigestion
  • Known severe kidney problems
  • Pregnant or breastfeeding
  • Unable to give consent

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

28 participants in 2 patient groups

FullAA
Active Comparator group
Description:
Amino acid drink containing all amino acids
Treatment:
Dietary Supplement: Ingestion of an amino acid supplement
NoBCAA
Active Comparator group
Description:
Amino acid drink containing all amino acids except for BCAAs.
Treatment:
Dietary Supplement: Ingestion of an amino acid supplement

Trial contacts and locations

0

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Central trial contact

Marlou Dirks, PhD

Data sourced from clinicaltrials.gov

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