BCAAs, Muscle Protein Synthesis and Glucose Uptake

Wageningen University

Status: Enrolling

Conditions: Healthy

Treatments: Dietary Supplement: Ingestion of an amino acid supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT06218264

NL82984.028.23

Details and patient eligibility

About

The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.

Full description

Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).

Enrollment: 28 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged from 18-35 years
• 18.5 < Body mass index < 30 kg·m2
• Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)

Exclusion criteria

• Smoking
• Diabetes (Type 1, Type 2, or genetic form of diabetes)
• Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
• Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
• Known allergy to lidocaine
• Regular use of dietary protein and/or amino acid supplements (>3 times per week)
• Currently involved in a structured progressive resistance training programme (>3 times per week)
• A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
• Any previous motor disorders or disorders in muscle and/or lipid metabolism
• Presence of an ulcer in the stomach or gut and/or strong history of indigestion
• Known severe kidney problems
• Pregnant or breastfeeding
• Unable to give consent

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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28 participants in 2 patient groups

FullAA

Active Comparator group

Description:

Amino acid drink containing all amino acids

Treatment:

Dietary Supplement: Ingestion of an amino acid supplement

NoBCAA

Active Comparator group

Description:

Amino acid drink containing all amino acids except for BCAAs.

Treatment:

Dietary Supplement: Ingestion of an amino acid supplement