Bed Rest, Alternate Daily Fasting and Incretin Effect

Rigshospitalet

Status: Completed

Conditions: Critical Illness; Type 2 Diabetes; Metabolic Syndrome

Treatments: Other: IVGTT; Other: Muscle and fat biopsies; Other: MRI; Other: Dual-energy X-ray Absorptiometry (DXA) scan; Other: Bed rest; Other: OGTT; Other: Cognitive testing

Study type: Interventional

Funder types: Other

Identifiers

NCT02134860

H-6-2014-017

Details and patient eligibility

About

Bed rest produces insulin resistance in healthy volunteers. In this study the investigators aim to investigate the effect of 8 days bed rest on the incretin effect and how alternate daily fasting affects cognitive function and the insulin resistance produced by bed rest.

The subjects will be randomized to either 3 meals a day (isocaloric diet), alternate daily fasting or one meal/day every second day (25% of daily calorie need) and four meals/day every second (175% of daily calorie need).

The investigators hypothesize:

1. Bed rest reduces the incretin effect
2. Alternate daily fasting improves the cognitive function (memory and concentration) compared to isocaloric diet
3. Alternate daily fasting reduces insulin resistance produced by bed rest compared to isocaloric diet

Full description

All subjects will undergo 8 days of bedrest. Outcome measures will be performed before, under and immediately after the bed rest period.

The individual study period will be 10 days in total.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI<25kg/m2
• VO2 max normal for age

Exclusion criteria

• Tobacco smoking
• Alcohol ingestion > 14 units per week
• Diabetes in nearby relatives
• Resection of the small intestine
• History of gastric bypass surgery
• Risk of deep venous thrombosis
• Female

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Isocaloric diet

Active Comparator group

Description:

3 daily meals

Treatment:

Other: IVGTT

Other: Bed rest

Other: MRI

Other: OGTT

Other: Cognitive testing

Other: Dual-energy X-ray Absorptiometry (DXA) scan

Other: Muscle and fat biopsies

Alternate daily fasting

Active Comparator group

Description:

One meal (25% of caloric need) every second day and four meals (175% of caloric need) every second day

Treatment:

Other: IVGTT

Other: Bed rest

Other: MRI

Other: OGTT

Other: Cognitive testing

Other: Dual-energy X-ray Absorptiometry (DXA) scan

Other: Muscle and fat biopsies