Bed Rest, Inactivity and Early Responses (BIER)

University of Exeter

Status: Completed

Conditions: Metabolic Responses to Inactivity

Treatments: Other: Physical inactivity

Study type: Interventional

Funder types: Other

Identifiers

NCT02981927

157758/02

Details and patient eligibility

About

To evaluate the early metabolic responses (whole body and within muscle tissue) to a single day of whole body physical inactivity (i.e. bed-rest), and evaluate the contribution of inactivity per se vs alterations in diet

Enrollment: 10 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy and aged 18-40 y
• BMI between 18 and 30

Exclusion criteria

• On medication
• Family history of metabolic disease
• Diagnosed with any metabolic or cardiovascular conditions
• BMI < 18 or > 30

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 3 patient groups

Control

No Intervention group

Description:

24 h habitual physical activity fed in energy balance

Bed rest matched diet

Experimental group

Description:

24 hour period of whole body bed-rest with a matched diet

Treatment:

Other: Physical inactivity

Bed rest balanced diet

Experimental group

Description:

24 hour period of whole body bed-rest fed in energy balance

Treatment:

Other: Physical inactivity