Bed-rest, Muscle Mass and Insulin Sensitivity

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Disuse Atrophy

Treatments: Behavioral: Bed rest

Study type: Interventional

Funder types: Other

Identifiers

NCT02109380

METC 14-3-013

Details and patient eligibility

About

In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

Enrollment: 15 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Aged from 18-35 years
• 18.5 < BMI < 30 kg/m2

Exclusion criteria

• Smoking
• Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
• Hypertension (according to WHO criteria) and/or cardiovascular disease
• Any back/leg/knee/neck/postural complaints
• Use of any prescribed medication
• Type 2 diabetes mellitus
• Any family history of thrombosis
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Myocardial infarction within the last 3 years
• Use of anti-coagulants

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

15 participants in 1 patient group

Bed rest

Experimental group

Description:

One week of bed rest.

Treatment:

Behavioral: Bed rest