Bedrest, Feeding Pattern, and Insulin Sensitivity

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Insulin Resistance; Atrophy, Disuse

Treatments: Other: Continuous feeding pattern; Other: Intermittent feeding pattern

Study type: Interventional

Funder types: Other

Identifiers

NCT02521025

MEC 15-3-035

Details and patient eligibility

About

In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.

Full description

In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18.5 and 35
• Recreationally active

Exclusion criteria

• Type 2 diabetes
• Performing progressive resistance training in 6 months prior to study
• Back/knee/leg problems
• Hypertension
• Use of certain anticoagulants
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs
• Blood donation in past 3 months

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Intermittent feeding

Experimental group

Description:

Intermittent feeding pattern throughout the bedrest period, with 4 boluses per day

Treatment:

Other: Intermittent feeding pattern

Continuous feeding

Experimental group

Description:

Continuous feeding pattern throughout the bedrest period, with 4 boluses per day, without breaks in food supply.

Treatment:

Other: Continuous feeding pattern