Beetroot Juice and Postprandial Vascular Activity

Maastricht University Medical Centre (MUMC)

Status

Completed

Conditions

Dyslipidemia

Treatments

Dietary Supplement: Beetroot Juice with oral fat load

Dietary Supplement: Carbohydrate control drink with oral fat load

Study type

Interventional

Funder types

Other

Identifiers

NCT01559441

METC 11-3-085

Details and patient eligibility

About

Increased postprandial lipemia may increase the risk for cardiovascular diseases. An important mechanistic link between lipemia following a high-fat meal and adverse cardiovascular events is lipid-mediated endothelial activation. Therefore, it is important to identify nutrients that can neutralize this acute vascular disturbance.

The investigators hypothesize that beetroot juice, a food rich in inorganic nitrate, could improve vascular activity during the postprandial phase.

Enrollment

20 patients

Sex

Male

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged between 18 and 70 years
Quetelet-index between 28-35 kg/m2
Mean serum triacylglycerol ≤1.7 mmol/L
No indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
No current smoker
No diabetic patients or individuals receiving antidiabetic medication
No familial hypercholesterolemia
No abuse of drugs
Less than 21 alcoholic consumptions per week
Stable body weight (weight gain or loss <3 kg in the past three months)
No use of medication known to affect serum lipid metabolism
No severe medical conditions that might interfere with the study, such as high blood pressure, epilepsy, asthma, allergies, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis
No active cardiovascular disease like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebro vascular accident)
Willingness to stop the consumption of foods rich in nitrates 3 weeks before the start of the study. Vegetables such as beets, celery, radishes, turnips and spinach are rich in nitrates
Willingness to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
No difficult venipuncture as evidenced during the screening visits

Exclusion criteria

Women
Quetelet-index between <28 or >35 kg/m2
Mean serum triacylglycerol ≥1.7 mmol/L
Indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
Current smoker
Diabetic patients or individuals receiving antidiabetic medication
Familial hypercholesterolemia
Abuse of drugs
More than 21 alcoholic consumptions per week
Unstable body weight (weight gain or loss >3 kg in the past three months)
Use of use of medication known to affect serum lipid metabolism
No severe medical conditions that might interfere with the study, such as high blood pressure, epilepsy, asthma, allergies, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis
Active cardiovascular disease like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebro vascular accident)
Use of an investigational product within the previous 1 month
Not willing to stop the consumption of foods rich in nitrates 3 weeks before the start of the study
Not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study, during the study or for 4 weeks after completion of the study
Not or difficult to venipuncture as evidenced during the screening visits