Beetroot Juice Resistance Training Older Adults

Wake Forest University (WFU)

Status: Completed

Conditions: Old Age; Atrophy; Sarcopenia

Treatments: Dietary Supplement: BRJ+Nitrate; Dietary Supplement: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT05460351

IRB00025941

Details and patient eligibility

About

The present study compared the effects of a nitrate containing beetroot juice supplement (BRJ+Nitrate) vs. a placebo (Control) on total and regional fat free mass, quadriceps muscle strength, lower body mobility, and VO2peak in healthy, older adults undergoing a 10-week long progressive resistance training program with protein supplementation.

Enrollment: 24 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Able to provide own transportation to study testing visits and intervention
• Able to read and write in English
• Nondiabetic, i.e. fasting glucose < 126 mg/dl
• Sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no more than 10 minute blocks and not participating in a resistance exercise training program)
• Willingness to provide informed consent and participate in intervention. Participants with diagnosed depression were permitted to participate provided that they have been medically stable without medication change for at least 3 months.

Exclusion criteria

• Smoking or use of chewing tobacco
• Involved in another intervention research study
• Diabetic (type 1 or 2)
• Atrophic gastritis
• Hypo- or hyperthyroidism
• Gout or history of kidney stones
• History of hypotension
• Premenopausal (women)
• Aversion to study-related testing procedures
• Allergy/sensitivity/aversion to beetroot beverages or protein supplement
• Medical conditions with contraindications for engaging in resistance training program or taking the protein supplement
• Systemic, uncontrolled diseases (diabetes, recent (last 6 months) or current treatment of cancer, thyroid disorders, cardiovascular disease, COPD, or inflammatory bowel diseases)
• Use of any of the following medications: phosphodiesterase type 5 inhibitors, nitroglycerin or nitrate preparations, proton pump inhibitors, or medications for hypothyroidism
• Potential inability to complete the tasks required for the protocol as well as conditions that may interfere with interpretation of results including: inability to ambulate, severe congestive heart failure or severe cardiovascular disease, neoplasm for practical and neurophysiologic reasons
• Individuals with contraindications for performing a graded exercise test or have medical contraindications for participating in a scheduled exercise training program
• Individuals more than 300 pounds or less than 125 pounds due to DEXA weight limits and possibility of exceeding recommended daily nitrate dose of 7 mg/kg body weight, respectively.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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24 participants in 2 patient groups, including a placebo group

BRJ+Nitrate

Experimental group

Description:

This arm underwent a 3 days a week, 10 weeks of resistance exercise training program and consumed for a 70 mL bottle of beetroot juice containing 380 mg of nitrate plus a 15 dose of whey protein after each exercise session.

Treatment:

Dietary Supplement: BRJ+Nitrate

Control

Placebo Comparator group

Description:

This arm underwent a 3 days a week, 10 weeks of resistance exercise training program and consumed for a 70 mL bottle of beetroot juice containing 0 mg of nitrate plus a 15 dose of whey protein after each exercise session.

Treatment:

Dietary Supplement: Control