Before and After Erythrocyte Suspension Transfusion

Afyonkarahisar Health Sciences University

Status: Completed

Conditions: Anemia; Oxidative Stress

Treatments: Other: Before Erythrocyte Suspension (ES); Other: After Erythrocyte Suspension (ES)

Study type: Interventional

Funder types: Other

Identifiers

NCT04212819

2015/7-165

Details and patient eligibility

About

Hypoperfusion, hypoxia and ischemia occurs in circulation as a result of anemia. All of these situations lead to oxidative stress and endothelial dysfunction in the organism. In this study, the investigators aimed to investigate the oxidant-antioxidant balance and asymmetric dimethylarginine (ADMA) levels in patients that have symptomatic anemia in need of erythrocyte suspension (ES) transfusion. To the best of the investigators knowledge, there have been few studies in the literature on anemia and total oxidant, total antioxidant and ADMA levels. We aimed to observe changes in oxidative - antioxidant ADMA levels before and after ES transfusion.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Only patients with deep anemia and anemia due to gastrointestinal bleeding patients in need of erythrocyte suspension transfusion were included.

Exclusion criteria

• Patients with history of hypertension, diabetes, coronary artery disease, congestive heart failure, chronic renal failure, liver failure were not included to the study

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Before erythrocyte suspension (ES) transfusion group

Experimental group

Description:

50 (Female/Male: 25/25) patients were included in this study. Total antioxidant status (TAS), total oxidant status (TOS) and ADMA levels were measured from the patients after diagnoses of anemia.

Treatment:

Other: Before Erythrocyte Suspension (ES)

After erythrocyte suspension transfusion group

Experimental group

Description:

24 hours after ES transfusion, total antioxidant status (TAS), total oxidant status (TOS) and ADMA levels were measured from the patients.

Treatment:

Other: After Erythrocyte Suspension (ES)