Behavioral and Neural Representations of Subjective Effort Cost

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Status: Enrolling

Conditions: Fatigue

Treatments: Behavioral: Physical Fatigue; Behavioral: Rewarding Stimuli; Behavioral: Cognitive Fatigue

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04041154

1R56MH113627-01A1 (U.S. NIH Grant/Contract)

IRB00034447 & IRB00283000

Details and patient eligibility

About

The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.

Full description

How effortful a task feels is an integral aspect of human decision-making that shapes motivation. If a task feels very effortful one may be unwilling to perform the work required, whereas if a task feels less effortful one may be more likely to persevere. Despite the importance of these perceptions for decision-making, the behavioral and neural mechanisms of subjective effort valuation are not well understood. Furthermore, the National Institutes of Mental Health (NIMH) Research Domain Criteria (RDoC) has identified "Effort Valuation / Willingness to Work" as a key subconstruct for understanding deficits in motivated performance in mental disorders. The goal of this proposal is to understand the mechanisms of subjective valuation of physical and cognitive effort, and the common and distinct systems that underlie these representations. To this end, a combination of experiments in healthy human participants, computational modeling of behavior, and functional magnetic resonance imaging (fMRI) will be used. Aim 1 will identify common and distinct physical and cognitive effort valuation mechanisms. Computational models will be used to characterize participants' subjective valuation of physical and cognitive effort, and to test if there are similarities in subjective preferences for these different types of effort. Model-based fMRI will be used to examine the common and distinct brain regions that encode the subjective valuation of physical and cognitive effort, and the network of brain regions that incorporate such preferences to motivate effortful engagement. Aim 2 will investigate the behavioral and neural mechanisms by which physical and cognitive fatigue effect effort valuation. Participants will be fatigued with sustained physical or cognitive exertion to examine how being in a fatigued state influences subjective valuation of physical and cognitive effort; and associated signals in the brain's valuation network. Aim 3 will explore how motivational state modulates decisions to exert physical and cognitive effort. Choices for physical and cognitive effort will be paired with motivational cues (i.e., cues that formerly predicted reward) in order to modulate participants' motivational state. This manipulation will allow for behavioral and neural dissociations between motivation and effort valuation in order to understand how these processes interact to give rise to motivated physical and cognitive engagement. In sum, the proposed studies will have a broad impact on the field of decision-making by dissecting the behavioral and neural mechanisms responsible for physical and cognitive effort valuation. In the long term, these studies may reveal novel behavioral and neural markers to aid in the study, classification, and treatment of amotivation.

Enrollment: 185 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Right-handed
• Age between 18 and 35 years old - Male or female
• Any ethnicity

Exclusion criteria

Individuals with a history of any of the following will be excluded from the study:

• Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report)
• Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report)
• Metal in the head or eyes
• If they are pregnant or suspect that you may be pregnant
• If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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185 participants in 3 patient groups

Cognitive Fatigue

Experimental group

Description:

We will use a behavioral intervention. Participants will perform a cognitively demanding task, repeatedly, to induce cognitive fatigue.

Treatment:

Behavioral: Cognitive Fatigue

Physical Fatigue

Experimental group

Description:

We will use a behavioral intervention. Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.

Treatment:

Behavioral: Physical Fatigue

Rewarding Stimuli

Experimental group

Description:

We will use a behavioral intervention. Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.

Treatment:

Behavioral: Rewarding Stimuli