Behavioral Assessment of Nociception on NCS-R

Hangzhou Normal University

Status: Completed

Conditions: Unresponsive Wakefulness Syndrome; Minimally Conscious State; Disorder of Consciousness

Treatments: Diagnostic Test: The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

Study type: Observational

Funder types: Other

Identifiers

NCT04137497

2017N54965

Details and patient eligibility

About

The aim of this study was to investigate the relationship between behaviorally assessed consciousness levels and responsiveness to nociception in patients with disorders of consciousness (DOC)

Full description

Patients with a clinical consensus of DOC were enrolled. The Coma Recovery Scale-Revised (CRS-R) was used to assess the DOC patients' consciousness levels and the Nociception Coma Scale-Revised (NCS-R) was used to evaluate their pain response over one week. Furthermore, the relationship between behaviorally assessed consciousness levels and pain response was analyzed.

Enrollment: 140 patients

Sex: All

Ages: 20 to 84 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (1) at least 18 years old
• (2) acquired brain injury
• (3) no neuromuscular blockers or sedatives used within 72 hours of enrollment.

Exclusion criteria

• (1) functional disorders caused by progressive mental diseases
• (2) persistent seizures
• (3) unstable vital signs
• and/or (4) double upper-limb frustration, fracture.

Trial design

140 participants in 3 patient groups

Patients with disorders of consciousness

Treatment:

Diagnostic Test: The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

Patients with unresponsive wakefulness syndrome

Treatment:

Diagnostic Test: The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

Patients with minimally conscious state

Treatment:

Diagnostic Test: The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)