Behavioral Dynamics Between Infants With Visual Loss and Healthy Controls

Sun Yat-sen University

Status: Completed

Conditions: Behavioral Dynamics; Visual Impairment

Treatments: Other: Standardized video recording for behaviors

Study type: Observational

Funder types: Other

Identifiers

NCT03431207

CCPMOH2018-China-1

Details and patient eligibility

About

An individual senses the world and reflects feedbacks via independent behaviors. Such precise collaboration of the sensory and behavioral systems is fundamental to survival and evolution. When a sensory modality is altered, the behavioral system has the potential to fit in a substitute modality. However, the specific dynamics of human behaviors in response to sensory loss remain largely unknown due to the paucities of representative situations and large-scale samples.

Here, the investigators focused on thousands of human infants who suffered varying degrees of visual stimuli deficiency in early stages, while their behavioral systems remained sensitive and thus retained high behavioral plasticity. Having access to this unique population provides an unprecedented opportunity to investigate the effect of diverse visual conditions on the behavioral system.

Enrollment: 4,196 patients

Sex: All

Ages: Under 3 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Younger than 3 years of age

Exclusion criteria

• Any brain and mental illnesses, or other known illnesses that may affect the behavioral patterns

Trial design

4,196 participants in 3 patient groups

healthy group

Description:

For the "healthy" group, the visual acuity of both eyes was in the 95% referenced range with no structural abnormalities. The referenced range could be found in the following publication: Mayer, DL., et al. Monocular acuity norms for the Teller Acuity Cards between ages one month and four years. Investigative Ophthalmology & Visual Science. 36(3):671 (1995)

Treatment:

Other: Standardized video recording for behaviors

mildly impaired group

Description:

The "mildly impaired" group was defined as a VA out of the 95% reference range in at least 1 eye, but the VA of both eyes was in the 99% referenced range with structural abnormalities.

Treatment:

Other: Standardized video recording for behaviors

severely impaired group

Description:

For the "severely impaired" group, the VA of both eyes was out of the 99% referenced range or worse than light perception with structural abnormalities.

Treatment:

Other: Standardized video recording for behaviors