Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

Yonsei University

Status: Completed

Conditions: Postprandial Hyperglycemia

Treatments: Dietary Supplement: Test 3; Dietary Supplement: Test 2; Dietary Supplement: Test 1; Dietary Supplement: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT02654301

Xylose_2015

Details and patient eligibility

About

The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

Full description

In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Enrollment: 80 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)

Exclusion criteria

1. history of taking an insulin-injection or oral hypoglycemic agents
2. evidence of alcohol abuse or alcoholism
3. pregnancy or breast feeding
4. chronic gastrointestinal disorder
5. seriously abnormal liver or renal function
6. an occupation at risk of death when hypoglycemia occurs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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80 participants in 4 patient groups, including a placebo group

Control group

Placebo Comparator group

Description:

sucrose drink (Control, sucrose 50g + deionized water 100g)

Treatment:

Dietary Supplement: Control

5 g xylose group

Active Comparator group

Description:

5 g xylose (Test 1, sucrose : xylose = 10:1),

Treatment:

Dietary Supplement: Test 1

3.33 g xylose group

Active Comparator group

Description:

3.33 g xylose (Test 2, sucrose : xylose = 15:1)

Treatment:

Dietary Supplement: Test 2

2.5 g xylose group

Active Comparator group

Description:

2.5 g xylose (Test 3, sucrose : xylose = 20:1)

Treatment:

Dietary Supplement: Test 3