Benefit of CFAE Ablation (BOCA)

NHS Trust

Status: Completed

Conditions: Persistent Atrial Fibrillation

Treatments: Procedure: Radiofrequency catheter Ablation; Procedure: Radiofrequency catheter ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT01711047

09/H0605/97

Details and patient eligibility

About

The optimal strategy for catheter ablation of persistent atrial fibrillation is not clearly defined. This study investigates if Complex Fractionated Atrial Electrogram (CFAE) ablation in addition to pulmonary vein isolation and linear ablations improves single procedural success rate over a 12 month follow up period.

Enrollment: 120 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• persistent atrial fibrillation

Exclusion criteria

• previous catheter or surgical ablation for atrial fibrillation
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

PVI + Linear ablation

Active Comparator group

Description:

Arm A: patients have PVI and roof and mitral isthmus lines

Treatment:

Procedure: Radiofrequency catheter Ablation

PVI + linear ablation + CFAE

Active Comparator group

Description:

Arm B: patients have PVI + roof and mitral isthmus lines and CFAE ablation

Treatment:

Procedure: Radiofrequency catheter ablation