Benefits of Mild Body Exercises in Parkinson's Disease

University of Kansas

Status: Unknown

Conditions: Parkinson Disease

Treatments: Behavioral: Qigong exercise; Behavioral: Mild body exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03463330

STUDY00140835

Details and patient eligibility

About

The purpose of this study is to learn the effects of two mild body exercises on quality of life, non-motor symptoms, anxiety, depression, fatigue, sleep quality, cognition, and executive function on people with Parkinson's Disease (PD).

Enrollment: 65 patients

Sex: All

Ages: 45 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of idiopathic PD
• Currently taking levodopa with some improvement in motor symptoms, and on a stable dose for a minimum of 4 weeks prior to starting the study
• Hoehn & Yahr stage I to III (mild to moderate PD)

Exclusion criteria

• Mini Mental State Examination (MMSE) score < 24
• Central neurological diseases other than PD or prior major head trauma with loss of consciousness, including other forms of parkinsonism, uncontrolled or significant cardiovascular diseases, orthopedic or medical problems that would interfere with gait
• Being primarily wheelchair bound
• Deep brain stimulation
• Expected change in PD medications over the course of the study
• Subjects with MRI contraindications such as pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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65 participants in 2 patient groups

Intervention Group

Experimental group

Description:

Participation in the intervention group will involve a total of 14 visits over about 14 weeks to the study site, and then a 6-month follow-up evaluation. Participants will learn and practice the Qigong exercise during the study.

Treatment:

Behavioral: Qigong exercise

Control Group

Sham Comparator group

Description:

Participation in the intervention group will involve a total of 14 visits over about 14 weeks to the study site, and then a 6-month follow-up evaluation. Participants will learn and practice a mild body exercise during the study.

Treatment:

Behavioral: Mild body exercise