Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects (PRFMMFD)

Dr.Syed Asimuddin

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Procedure: Furcation Treatment with Allograft and GTR; Device: allograft and guided tissue regeneration (GTR) membrane (DFDBM and Healiguide); Device: autologous platelet-rich fibrin; Procedure: Furcation treatment with PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT02430519

11/98/12

Details and patient eligibility

About

Background: Furcation is the bifurcation or trifurcation of a multirooted tooth. It is an area of complex anatomic morphology difficult to debride by routine periodontal instrumentation. Multiple approaches have been used in an effort to treat the furcation Choukroun's platelet-rich fibrin (PRF), a second generation platelet concentrate has biochemical components which have well known synergetic effects on healing processes. The present study was conducted to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) in the treatment of mandibular molar Grade 2 furcation defects in comparison to allograft and guided tissue regeneration (GTR) membrane.

Full description

ABSTRACT Background: Furcation is the bifurcation or trifurcation of a multirooted tooth. It is an area of complex anatomic morphology difficult to debride by routine periodontal instrumentation. Multiple approaches have been used in an effort to treat the furcation Choukroun's platelet-rich fibrin (PRF), a second generation platelet concentrate has biochemical components which have well known synergetic effects on healing processes. The present study was conducted to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) in the treatment of mandibular molar Grade 2 furcation defects in comparison to allograft and guided tissue regeneration (GTR) membrane. MATERIALS AND METHODS: The study was designed as a randomized, prospective, parallel-arm, interventional clinical trial wherein 30 patients with periodontitis and grade II Mandibular furcation defects attending the Out Patient wing of the Department of Periodontics of a tertiary referral care hospital were equally divided into group A and group B. Patients in.Group A, were treated by the placement of PRF as a Graft and as a membrane at the surgical site , while in Group B, the defects were treated by the placement of Allograft and Healiguide collagen membrane. Plaque Index, Probing depth, Vertical clinical attachment level, Horizontal clinical attachment level, Gingival marginal level, and amount of bonefill using Radiovisiography were recorded at baseline and 9 months. Intra-group comparison of Mean scores between Group A and Group B was done using Paired t test and Inter-group comparison using independent sample t test. CONCLUSION Further studies evaluating the efficacy of PRF using a larger sample size should be performed to evaluate its true beneficial effects on long term basis in patients with mandibular molar Grade 2 furcation defects.

Enrollment: 22 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• One or more sites showing grade II furcation involvement in mandibular molars, with Probing pocket depth ≥ 5mm
• Vertical attachment level and horizontal level ≥3mm were considered.
• Patients who were systemically healthy, with no history of endodontic and periodontal treatment for the last 6 months, and no antibiotic usage for the last 6 months were included in the study. Care was taken to ascertain that the samples taken for the study were not allergic to any drugs nor to the graft materials used.

Exclusion criteria

• Patients with a history of diabetes, hypertension, on anticoagulant or steroid therapy (which could alter the effects of PRF), cardiac diseases, insufficient platelet counts and immunocompromised individuals were excluded from the study.
• Care was taken to exclude pregnant women and lactating mothers, smokers, patients with previous history of graft placement in the experimental site, and importantly those patients who were unable to maintain good oral hygiene (PI Score ≥ 1.5).
• If Grade II mobility was observed after phase I therapy in the experimental teeth, they were excluded

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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22 participants in 2 patient groups

11 Patients with Grade II Manibular Molar Furcation

Experimental group

Description:

Group A- Furcation Treatment with PRF

Treatment:

Procedure: Furcation treatment with PRF

Device: autologous platelet-rich fibrin

11 Patients with Grade II Mandibular Molar Furcation D

Experimental group

Description:

Group B- Furcation Treatment with Allograft and GTR

Treatment:

Device: allograft and guided tissue regeneration (GTR) membrane (DFDBM and Healiguide)

Procedure: Furcation Treatment with Allograft and GTR