Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery

Coordinación de Investigación en Salud, Mexico

Status: Unknown

Conditions: Cardiovascular Surgical Procedure

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Observational

Funder types: Other

Identifiers

NCT03233815

R-2017-3604-95

Details and patient eligibility

About

This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous total anesthesia (TIVA) over inhaled anesthesia for this procedures.

Full description

IL-6, TNFα and cortisol will be measure at the beginning of the cardiovascular surgery and 20 minutes after the cardiovascular bypass ends to calculate the difference between them and compare if there is any statistical difference between the proinflammatory markers with the two anesthesia techniques.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Scheduled for cardiovascular surgery American Society of Anaesthesiologists (ASA) physical status classification II-IV BMI < 25 HbA1c < 7%

Exclusion criteria

Diabetic patients Known allergy to propofol

Trial design

40 participants in 2 patient groups

Inhaled anesthesia (Sevoflurane)

Description:

Patients undergoing cardiovascular surgery with inhaled anesthesia with sevoflurane.

Treatment:

Drug: Sevoflurane

Total Intravenous Anesthesia (Propofol)

Description:

Patients undergoing cardiovascular surgery with total intravenous anesthesia with propofol.

Treatment:

Drug: Propofol