Berry Components and Blood Sugar & Fat Metabolism

Beltsville Human Nutrition Research Center (BHNRC)

Status: Completed

Conditions: Healthy Volunteers

Treatments: Other: Fiber Enriched Jello; Other: Low Fiber Mixed Berry Juice; Other: Carbohydrate Control Jello; Other: Mixed Berry Diet

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT03458858

HS59

Details and patient eligibility

About

The primary objective of this study is to determine which components of berries improve glucose metabolism and increase fat oxidation in humans.

Full description

The aim of this study is to improve understanding of how diet can regulate glucose metabolism and fuel use. Previous human and animal studies have demonstrated that berries can improve gluco-regulation and increase fat oxidation. The aim of this study is to determine which component of berries is conveying this health benefit.

Enrollment: 36 patients

Sex: All

Ages: 21 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy non-smoker
• able to understand consent

Exclusion criteria

• Body Mass Index less than 25 kg/m2
• pregnant, lactating, having given birth in the past year
• allergy to berries
• blood glucose greater than 125 mg/dL
• history of bariatric surgery or nutrient malabsorption disease
• diagnosis or treatment of cancer in past three years
• type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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36 participants in 4 patient groups

Mixed Berry Diet

Other group

Description:

Participants will receive between 400 to 800 grams of mixed berries daily, as a proportion of their daily caloric intake added to their base diet. The base diet will be prepared using traditional American foods with a macronutrient composition representative of a typical American diet.

Treatment:

Other: Mixed Berry Diet

Carbohydrate Control Jello

Other group

Description:

Participants will receive between 400 to 800 grams of strawberry jello daily, as a proportion of their daily caloric intake added to their base diet. The jello will be matched to the mixed berries in both total carbohydrate level and gram quantity. The base diet will be prepared using traditional American foods with a macronutrient composition representative of a typical American diet.

Treatment:

Other: Carbohydrate Control Jello

Fiber Enriched Jello

Other group

Description:

Participants will receive between 400 to 800 grams of fiber enriched strawberry jello daily, as a proportion of their daily caloric intake added to their base diet. The jello will be matched to the mixed berries in both total carbohydrate level and fiber content, and in the same gram quantity. The base diet will be prepared using traditional American foods with a macronutrient composition representative of a typical American diet.

Treatment:

Other: Fiber Enriched Jello

Low Fiber Mixed Berry Juice

Other group

Description:

Participants will receive 1 liter per day of low fiber mixed berry juice added to their base diet. The juice will be squeezed from the mixed berries, then filtered. The sugar level of the juice will match that of the mixed berries. The base diet will be prepared using traditional American foods with a macronutrient composition representative of a typical American diet.

Treatment:

Other: Low Fiber Mixed Berry Juice