Best Cardiac Output During Cardiopulmonary Bypass

Aalborg University Hospital

Status: Completed

Conditions: Bypass Complications

Study type: Observational

Funder types: Other

Identifiers

NCT01379638

N-20080035

Details and patient eligibility

About

The purpose of this study is to determine whether the patients cardiac output measured before cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure.

Full description

For more than 50 years, CPB has been used to mechanically support the functions of the heart and lungs. In early studies, systemic oxygen uptake, calculated using Ficks global principle, was used to assess the efficiency of CPB. Using this measure of efficiency, a pump flow rate in liters per minute, based on the product of the body surface area (BSA) and a constant of 2.4 was found adequate to perfuse the body during normothermia. Ficks global principle is still used together with other methods to secure adequated perfusion under CPB.

The purpose of this study is to determine whether the patients cardiac output measured before CPB, is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure.

The hypothesis is that the patients cardiac output is a better marker for the optimal cardiac output than the estimated cardiac output.

Enrollment: 20 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients admitted for scheduled cardiac surgery during cardiopulmonary bypass
• Aged 18-90 years
• LVEF > 50 %
• written consent from the patients

Exclusion criteria

• Former cerebral emboli
• Former head trauma
• known stenosis of the arteria carotis

Trial design

20 participants in 1 patient group

cardiac output

Description:

Adult patients undergoing cardiac surgery with normothermic cardiopulmonary bypass