Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction (HFpEF-BB)

UConn Health

Status

Unknown

Conditions

Heart Failure With Preserved Ejection Fraction

Treatments

Other: beta blocker discontinuation

Study type

Interventional

Funder types

Other

Identifiers

NCT05174351

22-145-2

Details and patient eligibility

About

This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.

Full description

This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.

Enrollment

30 estimated patients

Sex

All

Ages

50 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
N=30 (Target: 30).
Age: 50 ~ 80 years.
ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
Chronic loop diuretic use
Currently on beta-blocker

Exclusion criteria

Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
Heart rate > 100 bpm
Recent hospitalization due to HF within 3 months
Non-English speaker