Beta-Cell Function After Near-Normalisation of Blood Glucose

Hvidovre University Hospital

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Drug: glucose dependent insulinotropic polypeptide; Drug: Saline; Drug: glucagon-like peptide-1,

Study type: Interventional

Funder types: Other

Identifiers

NCT00612950

KA 03005

Details and patient eligibility

About

The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.

Enrollment: 8 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-70 years
• Type 2 diabetes diagnosed after 30 years of age
• BMI > 25

Exclusion criteria

• Severe complications to diabetes
• Abnormal liver and kidney function
• Haemoglobin below the lower limit
• Macroalbuminuria
• Systemic disease
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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8 participants in 3 patient groups, including a placebo group

GLP-1

Experimental group

Treatment:

Drug: glucagon-like peptide-1,

GIP

Experimental group

Treatment:

Drug: glucose dependent insulinotropic polypeptide

saline

Placebo Comparator group

Treatment:

Drug: Saline