Beta-CIT-SPECT and Neurophysiology in Depression

Ludwig Maximilian University of Munich

Status and phase: Completed; Phase 4

Conditions: Depression

Treatments: Procedure: β-CIT-SPECT, Neurophysiology

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00145132

ESCIT-SPECT-Pogarell

EK287/98

Details and patient eligibility

About

Aim of this project is to investigate the effects of escitalopram on monoamine transporter (SERT, DAT) availabilities as assessed by b-CIT and SPECT, and on neurophysiological parameters such as the loudness dependence of auditory evoked potentials (LDAEP) in patients with depression.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Psychiatric in or outpatients with acute depressive episode
• Indication for pharmacological treatment

Exclusion criteria

• Acute suicidality
• Neurological or severe somatic disorders
• Occupational exposition to radiation >15 mSv per year
• Women during pregnancy or lactation

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)