Betamethasone to Control Postoperative Pain in Emergency Endodontic Care

Federal University of the Valleys of Jequitinhonha and Mucuri

Status: Completed

Conditions: Pain

Treatments: Drug: Placebo; Drug: Bethametasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02865746

ufvjm

Details and patient eligibility

About

The objective of this randomized double-blind study was to evaluate the effect of betamethasone in the control of postoperative pain in patients undergoing endodontic treatment.

Full description

To prevent post endodontic treatment pain, systemic administration of corticosteroids may have their effect maximized if the infiltration is performed in the oral mucosa, near the periapex of the tooth, which concentrates the inflammatory process. The administration of corticosteroids at this moment, taking advantage of the anesthetic effect still present, ensures continuous comfort during the postoperative period.

The objective of this randomized double-blind clinical trial was to evaluate the effect of the systemic administration of betamethasone - through infiltration in the oral mucosa - to control pain and edemas in patients undergoing emergency endodontic treatment.

Enrollment: 120 patients

Sex: All

Ages: 10 to 72 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals had to have a tooth with pain of endodontic origin justifying emergency care;
• Individuals diagnosed with irreversible pulpitis or necrosis associated to pericementitis.

Exclusion criteria

Individuals who presented:

• Pregnancy or lactation;
• Use of corticosteroids;
• History of hypersensitivity to the drugs used in this study;
• Pain associated with abscesses of endodontic origin;
• Individuals with tuberculosis;
• Individuals with systemic fungal infections;
• Individuals with simple ocular herpes;
• Individuals with glaucoma;
• Individuals with acute psychosis.
• Individuals with psychotic tendencies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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120 participants in 2 patient groups, including a placebo group

Group betamethasone

Active Comparator group

Description:

Active Comparator: betamethasone disodium phosphate at a concentration of 4 mg / ml - dosage of 0.05 mg / kg

Treatment:

Drug: Bethametasone

Group placebo

Placebo Comparator group

Description:

sterile saline solution (sodium chloride 0.9% - 1 ml ampoules) - dosage of 0.05 mg / kg

Treatment:

Drug: Placebo