Better Disease Control by Multidrug Regimen in Scabies

B.P. Koirala Institute of Health Sciences

Status: Completed

Conditions: Scabies

Treatments: Drug: Permethrin Lotion 5% and Oral Ivermectin 200 mcg/kg; Drug: Permethrin Lotion 5%

Study type: Interventional

Funder types: Other

Identifiers

NCT05198947

162/073/074-IRC

Details and patient eligibility

About

Scabies is associated with significant discomfort and social taboo. Existing treatment regimen frequently fails due to lack of patient compliance. We compared single use regimen to existing standard repeat application regimen for treatment of scabies.

Enrollment: 212 patients

Sex: All

Ages: 5 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Willing patients
• Clinical diagnosis of scabies
• Within the age limits

Exclusion criteria

• Unwilling patients
• Patients with severe co-morbidities requiring long term medication
• Pregnant women
• Patients who don't fulfill the age limit criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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212 participants in 2 patient groups

Group 1 Permethrin only

Active Comparator group

Description:

Standard regimen of permethrin 5% topical application to be repeated after 1 week.

Treatment:

Drug: Permethrin Lotion 5%

Group 2 Permethrin and Ivermectin

Active Comparator group

Description:

A combination regimen of permethrin 5% topical application with oral ivermectin 200 mcg/kg given on the single day only

Treatment:

Drug: Permethrin Lotion 5% and Oral Ivermectin 200 mcg/kg