Bevacizumab Versus Micropulse in Central Serous Chorioretinopathy (CSC)

Johann Wolfgang Goethe University Hospital

Status: Completed

Conditions: Central Serous Chorioretinopathy

Treatments: Device: subthreshold micropulselaser; Drug: bevacizumab

Study type: Interventional

Funder types: Other

Identifiers

NCT00802906

MK-RCS-2008

Details and patient eligibility

About

The purpose of this study is to evaluate the clinical efficacy of an initial subthreshold retinal micropulselasercoagulation versus a single intravitreal 1.5mg bevacizumab injection in central serous choriretinopathy, as the micropulse will selectively treat the damaged RPE to induce reproliferation of healthy RPE cells, whereas the intravitreal injection should non-selectively stop the RPE leakage.

Full description

To evaluate the clinical efficacy of an initial subthreshold retinal micropulselasercoagulation in twelve eyey per group versus a single intravitreal 1.5mg bevacizumab injection in central serous choriretinopathy, as the micropulse will selectively treat the damaged RPE to induce reproliferation of healthy RPE cells. BCVA in EDTRS score, OCT, and leakage in FLA, static perimetry of both groups will be correlated to a control group without treatment over 10 months.

Enrollment: 12 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CSC of >4 months duration

Exclusion criteria

• History of macular or chorioretinal inflammation
• Lens / corneal opacities

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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12 participants in 3 patient groups

1

Active Comparator group

Description:

1.5 mg bevacizumab single injection and on demand if leakage is persistent or recurs

Treatment:

Device: subthreshold micropulselaser

Drug: bevacizumab

2

Active Comparator group

Description:

initial selective subthreshold micropulselasercoagulation and on demand if leakage is persistent or recurs

Treatment:

Device: subthreshold micropulselaser

3

No Intervention group

Description:

control