"Beverage Hydration Index" of Commercial Therapeutic Beverages

Sonoma State University

Status: Completed

Conditions: Healthy

Treatments: Other: Water; Other: Pedialyte; Other: Gatorade; Other: enterade

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03262597

IRB Application #2667

Details and patient eligibility

About

The "beverage hydration index" (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric. Our purpose was to assess the BHI of beverages never previously tested, including an amino acid-based oral rehydration solution (AA-ORS), a glucose-containing ORS (G-ORS) and a sports drink (SD) compared to water (control).

Full description

The "Beverage Hydration Index" (BHI) was created to assess the degree to which beverages "hydrate", by measuring fluid retention after ingesting a 1 liter bolus and comparing it to water. Drinks with carbohydrates and electrolytes would traditionally be expected to score higher on the BHI due to glucose-sodium cotransport at the gut and osmolality approaching isotonicity with blood. One recent study reported that an oral rehydration solution (ORS) scored better than water, but a "sports drink" did not. No "optimal" BHI beverage composition has been described, nor has an optimal osmolality. Recently, a hypotonic amino acid-based rehydration beverage was developed to take advantage of amino acid-sodium cotransport, thus obviating the need for carbohydrate. However, the BHI of this beverage has not yet been assessed. The purpose of this investigation was to assess the hydration potential of this novel beverage in comparison to a commercially available carbohydrate-containing sports drink and oral rehydration solution.

Enrollment: 46 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male or female
• Aged 18-35
• BMI 18-27 kg/m2
• No known cardiovascular, renal or metabolic disease
• Moderately active
• Moderate alcohol use

Exclusion criteria

• Overweight or obese (BMI >27 kg/m2)

  • Competitive athletes during competition season

  • Current or former cardiovascular, renal or metabolic disease

  • Habitual consumption of alcohol (>21 units/week) or regular (>1/week) high (10 units) intake*

  • History of psychiatric illness

  • Actively seeking to gain or lose weight

  • Currently taking prescribed medication

    • Example, a 750 ml bottle of wine at 12% ABV contains 0.750 Liters * 12 = 9 units

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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46 participants in 1 patient group

Beverage Hydration Index of beverages

Experimental group

Description:

Subjects will consume 4 different beverages to obtain the beverage hydration index.

Treatment:

Other: enterade

Other: Pedialyte

Other: Gatorade

Other: Water