Bicarbonate in Patients With Out-of-hospital Cardiac Arrest

Asan Medical Center

Status and phase: Completed; Phase 2

Conditions: Metabolic Acidosis; Cardiac Arrest

Treatments: Drug: Normal saline; Drug: Sodium bicarbonate

Study type: Interventional

Funder types: Other

Identifiers

NCT02303548

BicarbonateinCPR001

Details and patient eligibility

About

A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult cardiac arrest patient with arterial pH <7.1 or bicarbonate <10mmEq/L checked at 10 minutes of cardiopulmonary resuscitation

Exclusion criteria

• age <18 trauma patient Do Not Resuscitate state

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups, including a placebo group

1 (Sodium bicarbonate)

Experimental group

Description:

Sodium bicarbonate 50cc (50mEq) intravenous injection over 2 min

Treatment:

Drug: Sodium bicarbonate

2 (Normal saline)

Placebo Comparator group

Description:

Normal saline 50cc intravenous injection over 2 min

Treatment:

Drug: Normal saline