Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit (HYDRAREA)

Caen University Hospital

Status and phase: Completed; Phase 3

Conditions: Contrast Induced Acute Kidney Injury

Treatments: Drug: saline; Drug: bicarbonates

Study type: Interventional

Funder types: Other

Identifiers

NCT01636089

2011-A00227-34

Details and patient eligibility

About

The aim of this study is to compare bicarbonates versus saline for prevention of contrast induced acute kidney injury in critically ill patients.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient > 18 years old
• in intensive care unit since 24h and for up to 48 hours
• with contrast medium injection

Exclusion criteria

• patient under renal replacement therapy
• rise in creatinine > 26µmol/L within 48hours
• anuria within 12 hours
• cardiogenic pulmonary oedema
• pH > 7.50 or kaliemia < 3mmol/L
• pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

---

300 participants in 2 patient groups

bicarbonates

Experimental group

Description:

sodium bicarbonates 1,4%

Treatment:

Drug: bicarbonates

saline

Active Comparator group

Description:

sodium chloride 0,9%

Treatment:

Drug: saline