Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery

Assiut University

Status: Unknown

Conditions: Postoperative Pain; Inflammatory Response

Treatments: Other: Ultrasound quadratus lumborum block with bupivacaine 25%; Other: lumbar epideural block with bupivacaine 25%

Study type: Interventional

Funder types: Other

Identifiers

NCT03958942

255

Details and patient eligibility

About

This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA II, III
• Weight 50 - 85 kg.
• Scheduled for major lower abdominal cancer surgery (radical cystectomy, total abdominal hysterectomy).

Exclusion criteria

• Patients with a history of relevant drug allergy.
• Coagulation disorders.
• Opioid dependence.
• Sepsis.
• Local infection at the vicinity of the block site.
• Patients with psychiatric illnesses that would interfere with perception and assessment of pain

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

quadratus lumborum block

Active Comparator group

Description:

received pre-emptive ultrasound-guided quadratus lumborum block with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of GA.

Treatment:

Other: Ultrasound quadratus lumborum block with bupivacaine 25%

lumbar epideural block

Active Comparator group

Description:

received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA.

Treatment:

Other: lumbar epideural block with bupivacaine 25%