Biliary Atresia Study in Infants and Children (BASIC)

Arbor Research Collaborative for Health

Status: Enrolling

Conditions: Biliary Atresia

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00345553

U01DK062456 (U.S. NIH Grant/Contract)

U01DK062500 (U.S. NIH Grant/Contract)

U01DK103135 (U.S. NIH Grant/Contract)

U01DK103149 (U.S. NIH Grant/Contract)

BASIC Study - ChiLDReN Network

U01DK062453 (U.S. NIH Grant/Contract)

U01DK084538 (U.S. NIH Grant/Contract)

U01DK062470 (U.S. NIH Grant/Contract)

U01DK084575 (U.S. NIH Grant/Contract)

U01DK103140 (U.S. NIH Grant/Contract)

U01DK062445 (U.S. NIH Grant/Contract)

U01DK062452 (U.S. NIH Grant/Contract)

U01DK062466 (U.S. NIH Grant/Contract)

U01DK062436 (U.S. NIH Grant/Contract)

U01DK062497 (U.S. NIH Grant/Contract)

U24DK062456 (U.S. NIH Grant/Contract)

U01DK062503 (U.S. NIH Grant/Contract)

U01DK084536 (U.S. NIH Grant/Contract)

U01DK062481 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To characterize the natural history of the older, non-transplanted child with BA.

Full description

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. A variety of genetic, autoimmune and environmental influences have been hypothesized to be important. Most studies to date have focused on the neonate and young child with BA, yet the older surviving child with BA can provide important information about genetics, as well as, natural history.

The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following hypotheses:

Hypothesis 1: A genetic defect is a likely causative factor for BA among children with BA and multiple congenital anomalies.

Hypothesis 2a: Sentinel events such as variceal bleeding, ascites and growth failure are earlier predictors of death or need for liver transplantation than the pediatric end-stage liver disease score (PELD).

Hypothesis 2b: Health related quality of life will be impaired compared to healthy age matched children and relate to severity of illness.

Hypothesis 2c: Growth failure as measured by anthropometrics and nutritional supplementation will be predictive of onset of sentinel events (ascites, variceal bleed, death, and transplant) in the following 24 months.

This study will be performed by the Childhood Liver Disease Research Network (ChiLDReN), a National Institute of Diabetes & Digestive and Kidney Diseases (NIDDK) funded network.

Enrollment: 1,265 estimated patients

Sex: All

Ages: 6 months to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Participants need to have a confirmed diagnosis of BA determined by chart review including review of pertinent diagnostic biopsy reports, radiologic reports and surgical reports (if surgery was performed).
2. Participants need to be >6 months of age up to and equal to the age of 20 (participants enrolled at 20 years of age will have one visit).
3. Participants with their native liver.
4. Parent, guardian or participant (if 18 years of age or older) is willing to provide informed consent and, when appropriate, the participant is willing to assent.

Exclusion criteria

1. Currently participating in the ChiLDReN study PROBE.
2. Inability to confirm original diagnostic evaluation of biliary atresia.
3. Inability or unwillingness of family or participant to participate in all scheduled visits.
4. History of liver transplantation.

Trial design

1,265 participants in 1 patient group

1

Description:

Biliary atresia subjects who have their native liver