Bimodal and Coaxial High Resolution Ophtalmic Imaging (AOSLO-OCT)

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

Status

Enrolling

Conditions

Hypertension

Diabetes

Retinal Detachment

Stroke

Retinal Degeneration

Macular Dystrophy

Glaucoma

Macular Edema

Retinitis Pigmentosa

Maculopathy, Age Related

Vascular Inflammation

Treatments

Other: Bimodal high resolution imaging of the retina

Study type

Interventional

Funder types

Other

Identifiers

NCT04620876

P16-02

2016-A00704-47 (Other Identifier)

Details and patient eligibility

About

The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging. However, optical aberrations of the ocular media limit the resolution that can be achieved by current techniques.

The use of an adaptive optics system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many retinal microstructures: photoreceptors, vessels, bundles of nerve fibers.

Recently, the development of the coupling of the two main imaging techniques, the Adaptive Optics Ophthalmoscope with Optical Coherence Tomography, enables unparalleled three-dimensional in vivo cell-scale imaging, while remaining comfortable for the patients.

The purpose of this project is to evaluate the performance of this system for imaging micrometric retinal structures.

Full description

The goal of the project is the capture and analysis of images with AOSLO system, in order to evaluate the performance of this system compared to OCT imaging devices and existing Adaptive Optics used at National Hospital of Ophthalmology.

Enrollment

1,200 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

People over 18
Patient with a pathology affecting the eye or healthy volunteer
Participant who signed the consent
Beneficiaries of the health insurance

Exclusion Criteria

Patients with a history of photosensitivity.
Patients who have just received a photodynamic therapy treatment
Patients taking drugs with photosensitivity as a side effect.
Persons with pacemakers or other implanted electronic medical device
Patients with viral conjunctivitis or any other infectious disease.
Patients with skin lesions on the neck or forehead
Patients at high risk of damage from optical radiation, such as aphakic patients, or patients with decreased sensitivity to light due to fundus disease.
Participant unable to be followed throughout the study
Advanced cataract or severe opacities in the anterior segment of the eye.