Bioactive Glass in the Treatment of Enamel White Spot Lesions

Rania Salah

Status and phase: Completed; Phase 3

Conditions: White Spot Lesion of Tooth

Treatments: Drug: Novamin; Drug: CPP-ACP; Drug: BiominF

Study type: Interventional

Funder types: Other

Identifiers

NCT04401280

WSL treatment

Details and patient eligibility

About

the aim of this study is to evaluate the effectiveness of BiominF® and Novamin® in comparison to Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in the treatment of enamel white spot lesions

Enrollment: 60 patients

Sex: All

Ages: 14 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Not less than 1 white spot lesion on the labial surface of teeth in the anterior region with code 2 International Caries Detection and Assessment System II (ICDAS-II) or less
• Absence of any active periodontal disease.
• Written informed consent

Exclusion criteria

• Known hypersensitivity/allergy to study products and/or materials used
• teeth having deep carious lesions or extensive restorations
• Unwillingness to be randomly assigned to 1 of the 3 treatment groups
• Advanced periodontal disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

BiominF®

Active Comparator group

Description:

Test group

Treatment:

Drug: BiominF

Novamin®

Active Comparator group

Description:

Test group

Treatment:

Drug: Novamin

CPP-ACP

Active Comparator group

Description:

Control group

Treatment:

Drug: CPP-ACP