Bioavailability of Aronia Melanocarpa

Maastricht University Medical Centre (MUMC)

Status

Enrolling

Conditions

Kinetics

Bioavailability

Treatments

Dietary Supplement: Aronia Melanocarpa extract

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT06306911

BB-BAM

Details and patient eligibility

About

The main objective of this study is to study the bioavailability and kinetics of acute Aronia Melanocarpa supplementation in healthy young (18-35 years) and older adults (55-75 years) adults. During the test day, participants will ingest a drink consisting of Aronia Melanocarpa extract (AME). The bioavailability and kinetics of AME will be assessed via frequent blood sampling, urine collection, and faecal sampling, in which AME and metabolite profiles will be quantified.

Enrollment

16 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

BMI between 18-35 kg/m2
Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg
Stable body weight (weight gain or loss < 3 kg in the past three months)
Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study

Exclusion criteria

Smoking or smoking cessation < 12 months
Severe medical conditions, including asthma, kidney failure, auto-inflammatory diseases, rheumatoid arthritis, diabetes mellitus, cardiovascular disease, gastrointestinal disorders such as Crohn's disease, colitis
Use of dietary supplements or medication affecting the main outcomes of the study (e.g. affecting gut metabolism, blood pressure medication)
Use of an investigational product within another biomedical intervention trial within the previous month
Abuse of drugs
More than 3 alcoholic consumptions per day
Known pregnancy or lactation
Known allergy to study product
Difficult venepuncture