Bioavailability of Avenanthramide-Enriched Oats in Healthy Older Adults

Tufts University

Status

Completed

Conditions

Healthy

Treatments

Other: Avenanthramide-enriched oats

Study type

Interventional

Funder types

Other

Identifiers

NCT01055717

IRB9306

Details and patient eligibility

About

This is a placebo-controlled, crossover study investigating the pharmacokinetic bioavailability of avenanthramides from avenanthramide-enriched oats and their in vivo metabolites in a cohort of healthy, older adults.

Enrollment

12 patients

Sex

All

Ages

50 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Men and postmenopausal women
BMI 18.5-29.9 kg/m2

Exclusion criteria

Cigarette smoking and/or nicotine replacement use
Use of cholesterol-lowering medications
Use of blood pressure-lowering medications
Use of any stomach acid-lowering medications
Cardiovascular (heart) disease
Gastrointestinal disease
Kidney disease
Endocrine disease: including diabetes, untreated thyroid disease
Rheumatoid arthritis
Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
Systolic blood pressure > 150 mm Hg and/or diastolic blood pressure > 95 mm Hg
Regular use of oral steroids
Regular daily intake of 2 or more alcoholic drinks
Illicit drug use
No fish oil supplements (including cod liver oil) for one month prior to study admission
No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission