Bioavailability of Carotenoids and Flavonoids From Fresh Oranges and Orange Juice.

University of Hohenheim

Status: Unknown

Conditions: Healthy

Treatments: Other: Fresh orange fruit and pasteurized fruit juice

Study type: Interventional

Funder types: Other

Identifiers

NCT02380144

F-2013-097

Details and patient eligibility

About

The study was designed as a randomized 2-way cross-over study to assess the bioavailability of carotenoids and flavonoids from sweet oranges and orange juice. Volunteers followed a wash-out period for 2 weeks prior to eating either 400 g of fresh oranges or 719 g of orange juice. The amount of test food was adjusted to deliver an equal amount of β-cryptoxanthin (740 µg). After a consecutive wash-out period of 2 weeks, the procedure was repeated and the volunteers ingested the complementary test food. Blood samples were collected at 8 time points up to 9.5 h after test meal consumption. Additionally, 24 h-urine was collected to evaluate flavonoid recovery.

Enrollment: 12 patients

Sex: All

Ages: 23 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult men and women
• BMI: 17-60
• Age: 18-65

Exclusion criteria

• Women who are lactating or pregnant or plan to be pregnant
• Individuals using tobacco products
• Individuals with metabolic or malabsorption disorders
• Individuals with a history of cancer
• Individuals with a history of liver insufficiency
• Individuals with a history of chronic and lipid metabolism-related diseases
• Individuals with an allergy to oranges
• Obese individuals (BMI > 30)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

12 participants in 2 patient groups

Orange Fruit - Orange Juice

Experimental group

Description:

Sequence of test foods during the intervention period: 1st: Orange fruit; 2nd: Orange juice

Treatment:

Other: Fresh orange fruit and pasteurized fruit juice

Orange Juice - Orange Fruit

Experimental group

Description:

Sequence of test foods during the intervention period: 1st: Orange juice; 2nd: Orange fruit

Treatment:

Other: Fresh orange fruit and pasteurized fruit juice