Bioavailability of Fatty Acids From Krill Oil and Krill Meal and Fatty Acids From Fish Oil in Healthy Subjects. (RISU)

Olympic Seafood

Status and phase: Completed; Phase 2

Conditions: Healthy

Treatments: Dietary Supplement: Krill oil; Dietary Supplement: Fish oil; Dietary Supplement: Krill meal

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02089165

RISU 58/2013

Details and patient eligibility

About

The purpose of the study is to compare the acute bioavailability of two different krill oil products called krill oil and krill meal in comparison to fish oil product.

Enrollment: 19 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy female and male
• Age 18 - 65 years
• Body mass index 18.5 - 30
• Informed consent, signed

Exclusion criteria

• Medication potential to affect the bioavailability of fatty acids (e.g. lipid-lowering drugs)
• Familial hypercholesterolemia, marked combined hyperlipidemia, condition that would impair, fat absorption (e.g. chronic pancreatitis, pancreatic lipase deficiency syndrome)
• Any untreated medical condition affecting absorption of fat
• Type 1 and 2 diabetes
• Cancer or other malignant disease within past five years
• Periodical hormone replacement therapy
• High intake of oily fish (once a week or more) (i.e. salmon, herring, sardines, mackerel, vendace)
• Smoking
• Alcohol consumption > 15 doses per week
• Females who are pregnant, breast-feeding or intend to become pregnant
• Hypersensitivity to any of the components of the test product
• Regular use of n-3 supplements 4 weeks before randomization
• Lack of suitability for participation in the trial, for any medical reason, as judged by the principal investigator

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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19 participants in 3 patient groups

Krill oil

Experimental group

Description:

The interventions are administered in the randomized order.

Treatment:

Dietary Supplement: Krill oil

Krill meal

Experimental group

Description:

The interventions are administered in the randomized order.

Treatment:

Dietary Supplement: Krill meal

Fish oil

Active Comparator group

Description:

The interventions are administered in the randomized order.

Treatment:

Dietary Supplement: Fish oil