Bioavailability of Fish Oils: Emulsified Versus Capsular Triglyceride

USDA Grand Forks Human Nutrition Research Center

Status: Completed

Conditions: Healthy Adults

Treatments: Dietary Supplement: Coromega Nectar; Dietary Supplement: Nordic Omega-3 Softgel; Dietary Supplement: Barleans Swirl; Dietary Supplement: Coromega Omega-3 Squeeze

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01488747

GFHNRC023

Details and patient eligibility

About

The primary objective of this investigation is to determine the relative percentage and rate of incorporation of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total omega-3 (n-3) fatty acids after ingestion of 4 emulsified flavored triglyceride fish oil supplements versus an encapsulated triglyceride in defined plasma lipid pools.

The primary endpoints to be evaluated include the fatty acid composition of plasma lipids before and after consumption of a single dose of emulsified triglyceride based fish oil and triglyceride of similar n-3 compositions in capsule form. The investigators will measure changes in plasma phospholipid, and chylomicron fatty acids.

Enrollment: 19 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Healthy adults ages 18 to 60.
2. Body mass index between 22 and 32 kg/m2.
3. Medical history (interview) demonstrating good health.
4. Nonsmoker.
5. Consumption of a typical American diet with no unusual dietary habits.
6. Willingness to comply with the study protocol.
7. Low reported n-3 intake (<100 mg/d) on the Omega-3 Checklist

Exclusion criteria

1. Any active, uncontrolled medical problem.
2. Consumption of essential fatty acid supplements within the past 6 months.
3. Use of lipid lowering drugs.
4. Fish consumption greater than 1 fish meal per week

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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19 participants in 4 patient groups

Coromega Omega-3 Squeeze

Experimental group

Description:

5.03 g

Treatment:

Dietary Supplement: Coromega Omega-3 Squeeze

Coromega Nectar

Experimental group

Description:

12.22 g

Treatment:

Dietary Supplement: Coromega Nectar

Barleans Swirl

Experimental group

Description:

17.45 g

Treatment:

Dietary Supplement: Barleans Swirl

Nordic Omega-3 Softgel

Active Comparator group

Description:

4 softgels

Treatment:

Dietary Supplement: Nordic Omega-3 Softgel